Curiously, TNFa was also identified to inhibit the expression of FLG and LOR by keratinocytes, and treatment method of psoriatic people with TNFa antagonists restored regular expression of FLG and LOR, in correlation with adjustments in psoriasis location and severity index
Preceding studies have revealed that TGF-b inhibits IFN-c-induced IDO activation in human monocytederived-macrophages , and abrogates IFN-c-induced IDO expression in human pores and skin and synovial fibroblasts in vitro at…