To examine the purpose of Cdc42 in Apoe KO mice, we crossed endothelial cell-certain Cdc42 CKO mice (Pdgfb-Cre-ER Cdc42loxP/loxP) with Apoe KO mice (Apoe2/two) to create Apoe KO Cdc42 CKO mice (Apoe2/2 Pdgfb-Cre-ER Cdc42loxP/loxP)
6 days after an infection, the cells had been transduced with three sets of siRNAs for RELA (1), siRNAs for IKKs (a, b, c subunits), or handle siRNA (siCont). Expression…