Our conclusion is based mostly on: 1) localization of the LHb subunit to the perinuclear region of cells, two) no detectable perinuclear staining of the LHbDT and LHbL119A mutants, and three) dispersion of FSHb subunit fluorescence all through the peripheral ER, with perinuclear staining for the FSHb-L chimera
Our prior conclusions indicated that the C-terminal heptapeptide in the LHb subunit was affiliated with a complex of intracellular determinative steps regarding the secretory destiny of LH dimer: Extent of…