In our experiments, vorinostat modulated the expression of cell cycle, apoptosis, and differentiation genes known to be altered in haematologic malignancies, rising expression of these genes normally down-controlled in MDS and/or AML
Given that the transcriptional effect of HDACi on some genes depends on TF that bind to proximal GC-wealthy DNA sequences, especially SP1 , we explored regardless of whether the transcriptional…