If cytotoxic effects are predominantly mediated from within the cell, then blocking the uptake of extracellular aggregates (or aggregation-prone proteins) into cells might be an effective way to prevent cytotoxicity
In electron microscopy experiments with immuno-labelling of Ure2 aggregates (info not revealed), formation of pores in the membrane could not be detected, while this has been described for Ab, a-synuclein,…