Product Name :
BGB-102
Description:
BGB-102 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.
CAS:
807640-87-5
Molecular Weight:
457.36
Formula:
C22H25BrN4O2
Chemical Name:
5-bromo-18-methoxy-10-methyl-16-oxa-2,10,21,23-tetraazatetracyclo[15.6.2.0³,⁸.0²⁰,²⁴]pentacosa-1(24),3,5,7,17(25),18,20,22-octaene
Smiles :
COC1=CC2=NC=NC3NC4=CC(Br)=CC=C4CN(C)CCCCCOC1=CC2=3
InChiKey:
JXDYOSVKVSQGJM-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7,10-12,14H,3-5,8-9,13H2,1-2H3,(H,24,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Telacebec Immunology/Inflammation
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BGB-102 is a potent multi-kinase inhibitor against EGFR, HER2, and HER4 with IC50s of 9.Nefazodone Adrenergic Receptor 6 nM, 18 nM and 40.PMID:33113334 3 nM, respectively.|Product information|CAS Number: 807640-87-5|Molecular Weight: 457.36|Formula: C22H25BrN4O2|Chemical Name: 5-bromo-18-methoxy-10-methyl-16-oxa-2,10,21,23-tetraazatetracyclo[15.6.2.0³,⁸.0²⁰,²⁴]pentacosa-1(24),3,5,7,17(25),18,20,22-octaene|Smiles: COC1=CC2=NC=NC3NC4=CC(Br)=CC=C4CN(C)CCCCCOC1=CC2=3|InChiKey: JXDYOSVKVSQGJM-UHFFFAOYSA-N|InChi: InChI=1S/C22H25BrN4O2/c1-27-8-4-3-5-9-29-21-11-17-19(12-20(21)28-2)24-14-25-22(17)26-18-10-16(23)7-6-15(18)13-27/h6-7,10-12,14H,3-5,8-9,13H2,1-2H3,(H,24,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|JNJ-26483327 (5 µM or 10 µM) with Herceptin treatment decreases HER2 phosphorylation in SKBR3 cells. JNJ-26483327 exerts greater inhibition of cell viability after 3, 6, or 8 d of treatment compared to Herceptin or JNJ-26483327 alone. JNJ-26483327 with TAPI-1 exerts less cell viability inhibition than Herceptin alone in both SKBR3 and BT474 cells.|In Vivo:|JNJ-26483327 (75 mg/kg, p.o.) delays xenograft tumour growth compared to vehicle treatment, but when combines with Herceptin, they can abrogate the PKB feedback loop and is synergistic in inhibition of xenograft tumour growth.|Products are for research use only. Not for human use.|