Product Name :
KO-947
Description:
KO-947 is a potent and selective inhibitor of ERK1/2 kinases. KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations.
CAS:
1695533-89-1
Molecular Weight:
355.39
Formula:
C21H17N5O
Chemical Name:
1,5,6,8-Tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-7H-pyrazolo[4,3-g]quinazolin-7-one
Smiles :
O=C1NC2=CC3NN=C(C=3C=C2CN1CC1C=CC=CC=1)C1C=CN=CC=1
InChiKey:
ODIUJYZERXVGEI-UHFFFAOYSA-N
InChi :
InChI=1S/C21H17N5O/c27-21-23-18-11-19-17(20(25-24-19)15-6-8-22-9-7-15)10-16(18)13-26(21)12-14-4-2-1-3-5-14/h1-11H,12-13H2,(H,23,27)(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KO-947 is a potent and selective inhibitor of ERK1/2 kinases.{{Paliperidone} MedChemExpress|{Paliperidone} Metabolic Enzyme/Protease|{Paliperidone} Technical Information|{Paliperidone} Formula|{Paliperidone} supplier|{Paliperidone} Epigenetic Reader Domain} KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations.{{Tedizolid} medchemexpress|{Tedizolid} Antibiotic|{Tedizolid} Protocol|{Tedizolid} Formula|{Tedizolid} manufacturer|{Tedizolid} Epigenetic Reader Domain} |Product information|CAS Number: 1695533-89-1|Molecular Weight: 355.39|Formula: C21H17N5O|Chemical Name: 1,5,6,8-Tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-7H-pyrazolo[4,3-g]quinazolin-7-one|Smiles: O=C1NC2=CC3NN=C(C=3C=C2CN1CC1C=CC=CC=1)C1C=CN=CC=1|InChiKey: ODIUJYZERXVGEI-UHFFFAOYSA-N|InChi: InChI=1S/C21H17N5O/c27-21-23-18-11-19-17(20(25-24-19)15-6-8-22-9-7-15)10-16(18)13-26(21)12-14-4-2-1-3-5-14/h1-11H,12-13H2,(H,23,27)(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 71 mg/mL (199.PMID:24957087 78 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Francis Burrows, et al. Cancer Res 2017;77(13 Suppl):AbstraProducts are for research use only. Not for human use.|