Product Name :
Daidzein-2c, Osteogenic Modulator
Description:
Daidzein-2c is a potent synthetic daidzein analog, has osteogenic induction potentials on human Mesenchymal Stem Cells (MSC). Human bone marrow derived mesenchymal stem cells from three different donors were treated with Daidzein-2c and shown to exhibit enhanced osteogenesis when compared to daidzein or estrogen treatment. The enhanced osteogenic induction by Daidzein-2c resulted in increased osterix (Sp7), alkaline phosphatase (ALP), osteopontin (OPN), and insulin-like growth factor 1 (IGF-1), which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells. It serves as a useful chemical tool to further validate and develop novel treatments of osteoporosis via promoting bone formation.
CAS:
97846-18-9
Molecular Weight:
296.32
Formula:
C18H16O4
Chemical Name:
3-(4-hydroxyphenyl)-7-isopropoxy-4H-chromen-4-one
Smiles :
CC(C)OC1=CC2OC=C(C(=O)C=2C=C1)C1C=CC(O)=CC=1
InChiKey:
DEQMUPGWSXUDKV-UHFFFAOYSA-N
InChi :
InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11,19H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{RGX-202} medchemexpress|{RGX-202} Apoptosis|{RGX-202} Purity & Documentation|{RGX-202} Formula|{RGX-202} custom synthesis|{RGX-202} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Daidzein-2c is a potent synthetic daidzein analog, has osteogenic induction potentials on human Mesenchymal Stem Cells (MSC). Human bone marrow derived mesenchymal stem cells from three different donors were treated with Daidzein-2c and shown to exhibit enhanced osteogenesis when compared to daidzein or estrogen treatment. The enhanced osteogenic induction by Daidzein-2c resulted in increased osterix (Sp7), alkaline phosphatase (ALP), osteopontin (OPN), and insulin-like growth factor 1 (IGF-1), which are osteogenic factors that regulate the maturation of osteogenic progenitor cells into more differentiated osteoblast cells.{{CASP8-IN-1} MedChemExpress|{CASP8-IN-1} Caspase|{CASP8-IN-1} TGF-beta/Smad|{CASP8-IN-1} Biological Activity|{CASP8-IN-1} Description|{CASP8-IN-1} custom synthesis} It serves as a useful chemical tool to further validate and develop novel treatments of osteoporosis via promoting bone formation.PMID:35116795 |Product information|CAS Number: 97846-18-9|Molecular Weight: 296.32|Formula: C18H16O4|Chemical Name: 3-(4-hydroxyphenyl)-7-isopropoxy-4H-chromen-4-one|Smiles: CC(C)OC1=CC2OC=C(C(=O)C=2C=C1)C1C=CC(O)=CC=1|InChiKey: DEQMUPGWSXUDKV-UHFFFAOYSA-N|InChi: InChI=1S/C18H16O4/c1-11(2)22-14-7-8-15-17(9-14)21-10-16(18(15)20)12-3-5-13(19)6-4-12/h3-11,19H,1-2H3|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Daidzein-2c was used at 1 µM final concentration in various in vitro assays.|References:|Amy L, et al. Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells. (2014) ACS Med. Chem. Lett., In press.Products are for research use only. Not for human use.|Documents||