Product Name :
Acoramidis
Description:
Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis.
CAS:
1446711-81-4
Molecular Weight:
292.31
Formula:
C15H17FN2O3
Chemical Name:
3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid
Smiles :
CC1NN=C(C)C=1CCCOC1=CC(=CC=C1F)C(O)=O
InChiKey:
WBFUHHBPNXWNCC-UHFFFAOYSA-N
InChi :
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis.|Product information|CAS Number: 1446711-81-4|Molecular Weight: 292.31|Formula: C15H17FN2O3|Chemical Name: 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid|Smiles: CC1NN=C(C)C=1CCCOC1=CC(=CC=C1F)C(O)=O|InChiKey: WBFUHHBPNXWNCC-UHFFFAOYSA-N|InChi: InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Neomycin} site|{Neomycin} Antibiotic|{Neomycin} Protocol|{Neomycin} Data Sheet|{Neomycin} manufacturer|{Neomycin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Fluphenazine} web|{Fluphenazine} Sodium Channel|{Fluphenazine} Biological Activity|{Fluphenazine} Data Sheet|{Fluphenazine} supplier|{Fluphenazine} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24456950 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Acoramidis (AG10, 0.1-10 μM for TTR ∼5 µM) stabilizes V122I- and WT-TTR equally well and also exceeds their efficacy to stabilize WT and mutant TTR in whole serum. Acoramidis (AG10) stimulates the mitochondrial QO2 in a concentration-dependent manner between 10 and 100 μM. Acoramidis (AG10) has very minimal inhibition of two common off-targets in drug discovery, the potassium ion channel hERG (IC50 > 100 µM) and a number of cytochrome P450 isozymes (IC50 > 50 µM) (low toxicity).|Products are for research use only. Not for human use.|