Product Name :
S-8921
Description:
S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.
CAS:
151165-96-7
Molecular Weight:
540.60
Formula:
C30H36O9
Chemical Name:
methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylpentanoyl)-4-hydroxy-6,7,8-trimethoxynaphthalene-2-carboxylate
Smiles :
COC(=O)C1=C(C2=C(OC)C(OC)=C(C=C2C(O)=C1C(=O)CC(CC)CC)OC)C1=CC(OC)=C(C=C1)OC
InChiKey:
QEJQEIIPZKQCNP-UHFFFAOYSA-N
InChi :
InChI=1S/C30H36O9/c1-9-16(10-2)13-19(31)25-26(30(33)39-8)23(17-11-12-20(34-3)21(14-17)35-4)24-18(27(25)32)15-22(36-5)28(37-6)29(24)38-7/h11-12,14-16,32H,9-10,13H2,1-8H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.|Product information|CAS Number: 151165-96-7|Molecular Weight: 540.60|Formula: C30H36O9|Chemical Name: methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylpentanoyl)-4-hydroxy-6,7,8-trimethoxynaphthalene-2-carboxylate|Smiles: COC(=O)C1=C(C2=C(OC)C(OC)=C(C=C2C(O)=C1C(=O)CC(CC)CC)OC)C1=CC(OC)=C(C=C1)OC|InChiKey: QEJQEIIPZKQCNP-UHFFFAOYSA-N|InChi: InChI=1S/C30H36O9/c1-9-16(10-2)13-19(31)25-26(30(33)39-8)23(17-11-12-20(34-3)21(14-17)35-4)24-18(27(25)32)15-22(36-5)28(37-6)29(24)38-7/h11-12,14-16,32H,9-10,13H2,1-8H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Resmetirom} web|{Resmetirom} Vitamin D Related/Nuclear Receptor|{Resmetirom} Biological Activity|{Resmetirom} Purity|{Resmetirom} supplier|{Resmetirom} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Oxacillin sodium} MedChemExpress|{Oxacillin sodium} Antibiotic|{Oxacillin sodium} Biological Activity|{Oxacillin sodium} In Vitro|{Oxacillin sodium} supplier|{Oxacillin sodium} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35116795 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. S-8921 inhibits the uptake velocity of 60 μM [3H] taurocholate dose-dependently in IBAT-COS cells, and the IC50 value of S-8921 is 66±8 μM.|In Vivo:|Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective.|Products are for research use only. Not for human use.|