5 + four) 9 (4 + five) 9 (4 + 5) eight (4 + four) 9 (four + five) eight (four + four) ISUP Grade on Biopsy 3 four 5 three 5 five five four five 5 five 4 4 four five 5 five five 5 4 five four Clinical T Stage T2c T1 T
five + 4) 9 (four + 5) 9 (four + five) eight (four + four) 9 (four + 5) eight (four + four) ISUP Grade on Biopsy 3 4 5 three 5 5 5 four five five 5 4 four four five 5 five five 5 four five 4 Clinical T Stage T2c T1 T2a T2c T1 T3b T2a T1 T2a T2b T2c T2a T1 T2a T2a T3b T2c T2c T2a T1 T2a TPSA: Prostate Precise Antigen; GS: Gleason Score; ISUP: International Society of Urological Pathology.3.2. PET/MRI Findings An example of whole-body biodistribution of 68 Ga-PSMA PET and 68 Ga-DOTA-RM2 PET is reported in Figure 1. Physiological high 68 Ga-PSMA uptake is usually visualised inside the salivary and lacrimal glands, liver, spleen, compact intestine, kidneys, urinary bladder and ureters (Figure 1A), even though 68 Ga-DOTA-RM2 showed physiological higher uptake inside the pancreatic gland and urinary bladder (Figure 1B). 68 Ga-PSMA PET detected intra-prostatic lesions in all patients, while 68 Ga-DOTA-RM2 PET identified the intraprostatic disease in 18/19 patients. Moreover, in 2/22 sufferers 68 Ga-PSMA PET also detected seminal vesicles uptake. The distinct web sites of intra-prostatic 68 Ga-PSMA and 68 Ga-DOTA-RM2 uptake are reported in Table 2.Diagnostics 2021, 11,7 ofTable 2. TNM findings of 68 Ga-PSMA, 68 Ga-RM PET/MRI and histological validation.n. Histological Specimen T Prostate (bilateral), ECE, left SVI Prostate (bilateral), ECE NA Prostate (bilateral, Bomedemstat Formula proper dominant nodule) NA NA Prostate (right) Prostate (bilateral, right dominant nodule), ECE Prostate (bilateral, left dominant nodule) Prostate (proper) Prostate (bilateral, left dominant nodule) Prostate (bilateral, left dominant nodule), ECE Prostate (bilateral, appropriate dominant nodule), ECE, SVI NA Prostate (bilateral, ideal dominant nodule), ECE N Left external iliac LN Negative NA M NA NA NA T Prostate (bilateral) Prostate (bilateral) Prostate (various ML-SA1 Biological Activity bilateral focal uptake), SVI Prostate (suitable) Prostate (bilateral) Prostate (left) Prostate (correct) Prostate (suitable) Prostate (left) Prostate (appropriate) Prostate (left) Prostate (left) Prostate (correct) Prostate (left) Prostate (left)68 Ga-PSMA 68 Ga-DOTA-RMMRI M Adverse Negative Adverse T Prostate (bilateral) Prostate (bilateral) Prostate (bilateral), SVI, ECE Prostate (ideal, several foci) Prostate (bilateral), SVI, ECE Prostate (left), ECE Prostate (ideal) Prostate (correct), ECE Prostate (left) Prostate (right), ECE Prostate (left), ECE Prostate (left), ECE Prostate (proper, bifocal) Prostate (left), ECE Prostate (proper) N Left external iliac Adverse Left external iliac, left pararectal, Negative left obturator, suitable obturator, external bilateral iliac Damaging Bilateral iliac Unfavorable Damaging Negative Unfavorable Damaging Unfavorable Damaging Negative M Negative Damaging Negative1 2N Left external iliac, left Perivescical fat Damaging Left external iliac, bilateral perirectal, presacral Unfavorable Left perivescical, bilateral obturator, left external iliac Left perirectal Bilateral external iliac, appropriate prevalent iliac Adverse Damaging Unfavorable Unfavorable Unfavorable Unfavorable Damaging NegativeM Adverse Right iliac bone NegativeT Prostate (bilateral) Prostate (bilateral) Prostate (bilateral) Prostate (correct) Prostate (bilateral) Prostate (left) Prostate (ideal) Prostate (right) Prostate (left) Prostate (right) Prostate (left) Prostate (left) Prostate (proper) Prostate (left) Prostate (proper)N Damaging Unfavorable left iliac, left perirectal hilomediastinic Left external iliac, left obturator Adverse Negative Adverse Damaging Unfavorable Unfavorable Adverse Unfavorable Unfavorable NegativeNegativeNANegativeNegativeNegative5 six 7 eight 9 10 11 12 13 1.