Heterocyclic moiety. 1 The IR-spectrumserves as characteristic N-O peaks at 1249 and 1313 cm–1. The N-oxide is really a relatively polar consists of compound. dark-red The IR-spectrum consists of characteristic N-O peaks at 1249 and 1313 cm-1. The N-oxide will be the IR-spectrum contains characteristic N-O peaks at 1249 and 1313 cm . The N-oxide is a relatively polar dark-red compound. Structures on the isolated merchandise recommend that di(benzo)quinoline skeleton fora comparatively polar dark-red compound. a somewhat polar dark-red compound. suggest that di(benzo)quinoline skeleton formation Structures of your isolated goods mation can proceed by two pathways illustrated in Scheme 7: either an intramolecular Structures di(benzo)quinoline skeleton forStructures on the isolated goods suggest that di(benzo)quinoline skeleton forcan proceed by of the isolated items suggest that 7: either an(for R=Me) or cyclizatwo pathways illustrated in Scheme addition of your amidine nitrogen atom, followed by fragmentation intramolecular addimation can proceed by two pathways illustrated in Scheme 7: either an intramolecular mation can proceed by two tion on the amidine with thepathways illustrated in Scheme 7: either an intramolecular tion ragmentation nitrogen atom, followed of an external nucleophile, e.g.,cyclizationparticipation by fragmentation (for R=Me) or water (for addition with the amidine nitrogen atom, followed by fragmentation (for R=Me) or cyclizaaddition of your amidine participation of an external nucleophile, (for R=Me) or R=Ph). fragmentation together with the nitrogen atom, followed by fragmentatione.g., water (forcyclizaR=Ph). These scenarios are consistent using the isolation in the fragmentation amide prodtion ragmentation together with the participation of an external nucleophile, e.g., water (for tion ragmentation together with the participation of of external nucleophile, e.g., water These scenarios are constant using the isolationan the fragmentation amide product. (for uct. R=Ph). These scenarios are constant together with the isolation on the fragmentation amide prodR=Ph). These scenarios are constant with the isolation from the fragmentation amide product. uct.Scheme 7. The common scheme for the formation on the two A 83-01 Autophagy varieties of Biocytin Metabolic Enzyme/Protease tetracyclic heterocyclic cores of tetracyclic heterocyclic from R-ethynyl-9,10-anthraquinones. Scheme 7. The common scheme for the formation on the two kinds of tetracyclic heterocyclic cores Scheme 7. The general scheme for the formation from the two forms of tetracyclic heterocyclic cores from R-ethynyl-9,10-anthraquinones. from R-ethynyl-9,10-anthraquinones.Molecules 2021, 26, x FOR Molecules 2021, 26, 6883 PEER REVIEW55 of 13 ofThe observed transformations, i.e., the formation of aroyl derivatives, are nicely conThe observed transformations, i.e., the formation of aroyl derivatives, are well consistent with all the idea of alkynes as chemical equivalents of carbonyls, described in our sistent using the notion of alkynes as chemical equivalents of carbonyls, described in our recent review. [6] current overview [6]. The resulting compounds are of considerable interest for healthcare chemistry, resulting from The resulting compounds are of considerable interest for healthcare chemistry, as a result of the relation with the 7H-dibenzo[de,h]quinoline-7-one skeleton to organic alkaloids on the the relation on the 7H-dibenzo[de,h]quinoline-7-one skeleton to all-natural alkaloids of the Isoaporphinoid series. Taking into consideration this relation, we explored biological activity of the new Isoaporphino.