Product Name :
Rabbit anti-PRSS8 Polyclonal Antibody
Synonym :
CAP1; Channel Activating Protease 1; mCAP1; Prostasin; Prostasin heavy chain; protease; serine; 8; Prss8; PRSS8_HUMAN; Serine protease 8
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
PRSS8
Predicted Reactivity:
Dog, Pig, Cow
Applications :
WB=1:500-2000
Immunogen:
KLH conjugated synthetic peptide derived from human PRSS8:65-165/343
Concentration :
1mg/ml
Purification :
affinity purified by Protein A
Clonality:
Polyclonal Antibody
Storage Temp.:
Store at -20 ° C for one yearAvoid repeated freeze/that cycles
Research areas :
Tumor Cell biology Kinases and phosphatases Tumor cell biomarkers
Background :
PRSS8 is a member of the trypsin family of serine proteases. It can be found in seminal fluid and is highly expressed in prostate epithelia. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. The carboxyterminal region contains a GPI anchor sequence, which anchors prostasin to the cell surface. Phospholipase activity is thought to liberate prostasin from the cell, and cleavage of the linker region also releases prostasin. PRSS8 has been proposed as a marker for ovarian cancer, where it is up-regulated, a marker for androgen-refractory prostate cancer, where it is down-regulated, and as an inhibitor of invasiveness in breast cancer.
UniProt :
Q16651
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym CAP1; Channel Activating Protease 1; mCAP1; Prostasin; Prostasin heavy chain; protease; serine; 8; Prss8; PRSS8_HUMAN; Serine protease 8 |Host Rabbit |Specificity PRSS8 |Species Reactivity Human, Mouse, Rat |Predicted Reactivity Dog, Pig, Cow |Applications WB=1:500-2000 |Usage WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user. |Immunogen KLH conjugated synthetic peptide derived from human PRSS8:65-165/343 |Properties |Concentration 1mg/ml |Purification affinity purified by Protein A |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ° C for one yearAvoid repeated freeze/that cycles |Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |Research areas Tumor Cell biology Kinases and phosphatases Tumor cell biomarkers |Target |Background PRSS8 is a member of the trypsin family of serine proteases. It can be found in seminal fluid and is highly expressed in prostate epithelia. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. The carboxyterminal region contains a GPI anchor sequence, which anchors prostasin to the cell surface. Phospholipase activity is thought to liberate prostasin from the cell, and cleavage of the linker region also releases prostasin. PRSS8 has been proposed as a marker for ovarian cancer, where it is up-regulated, a marker for androgen-refractory prostate cancer, where it is down-regulated, and as an inhibitor of invasiveness in breast cancer. |Cellular localization Cell membrane; Extracellular matrix; Secretory Proteins; |UniProt Q16651 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-PRSS8 Polyclonal Antibody
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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