Product Name :
6-Thio-2′-Deoxyguanosine
Description:
6-Thio-2′-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.
CAS:
789-61-7
Molecular Weight:
283.31
Formula:
C10H13N5O3S
Chemical Name:
(2R,3S,5R)-2-(hydroxymethyl)-5-(2-imino-6-sulfanyl-3,9-dihydro-2H-purin-9-yl)oxolan-3-ol
Smiles :
N=C1NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(S)=N1
InChiKey:
SCVJRXQHFJXZFZ-KVQBGUIXSA-N
InChi :
InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Minocycline Cancer
Additional information:
6-Thio-2′-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase.Tigecycline site |Product information|CAS Number: 789-61-7|Molecular Weight: 283.PMID:32851919 31|Formula: C10H13N5O3S|Chemical Name: (2R,3S,5R)-2-(hydroxymethyl)-5-(2-imino-6-sulfanyl-3,9-dihydro-2H-purin-9-yl)oxolan-3-ol|Smiles: N=C1NC2=C(N=CN2[C@H]2C[C@H](O)[C@@H](CO)O2)C(S)=N1|InChiKey: SCVJRXQHFJXZFZ-KVQBGUIXSA-N|InChi: InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (176.49 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Treatment with 6-Thio-2′-Deoxyguanosine results in rapid cell death for the vast majority of the cancer cell lines tested with IC50s of between 0.7-2.9 µM.|In Vivo:|In A549 lung cancer cell-based mouse xenograft studies, 6-Thio-2′-Deoxyguanosine causes a decrease of the tumor growth rate, superior to that observed with 6-thioguanine treatment. Additionally, 6-Thio-2′-Deoxyguanosine increases telomere dysfunction in tumor cells in vivo.|Products are for research use only. Not for human use.|