Product Name :
Ilexgenin A
Description:
Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer.
CAS:
108524-94-3
Molecular Weight:
502.68
Formula:
C30H46O6
Chemical Name:
(3S, 4R, 4aR, 6aR, 6bS, 8aS, 11R, 12R, 12aS, 14aR, 14bR)-3, 12-dihydroxy-4, 6a, 6b, 11, 12, 14b-hexamethyl-2, 3, 4, 4a, 5, 6, 6a, 6b, 7, 8, 9, 10, 11, 12, 12a, 14, 14a, 14b-octadecahydropicene-4, 8a(1H)-dicarboxylic acid
Smiles :
C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2[C@]1(C)O)C(O)=O
InChiKey:
UIEGOKVPCRANSU-XUFMHOFVSA-N
InChi :
InChI=1S/C30H46O6/c1-17-9-14-30(24(34)35)16-15-26(3)18(22(30)29(17,6)36)7-8-19-25(2)12-11-21(31)28(5,23(32)33)20(25)10-13-27(19,26)4/h7,17,19-22,31,36H,8-16H2,1-6H3,(H,32,33)(H,34,35)/t17-,19-,20-,21+,22-,25-,26-,27-,28-,29-,30+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer.|Product information|CAS Number: 108524-94-3|Molecular Weight: 502.68|Formula: C30H46O6|Chemical Name: (3S, 4R, 4aR, 6aR, 6bS, 8aS, 11R, 12R, 12aS, 14aR, 14bR)-3, 12-dihydroxy-4, 6a, 6b, 11, 12, 14b-hexamethyl-2, 3, 4, 4a, 5, 6, 6a, 6b, 7, 8, 9, 10, 11, 12, 12a, 14, 14a, 14b-octadecahydropicene-4, 8a(1H)-dicarboxylic acid|Smiles: C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)([C@@H]5CC[C@@]34C)C(O)=O)[C@@H]2[C@]1(C)O)C(O)=O|InChiKey: UIEGOKVPCRANSU-XUFMHOFVSA-N|InChi: InChI=1S/C30H46O6/c1-17-9-14-30(24(34)35)16-15-26(3)18(22(30)29(17,6)36)7-8-19-25(2)12-11-21(31)28(5,23(32)33)20(25)10-13-27(19,26)4/h7,17,19-22,31,36H,8-16H2,1-6H3,(H,32,33)(H,34,35)/t17-,19-,20-,21+,22-,25-,26-,27-,28-,29-,30+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Estradiol In Vitro |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Rocatinlimab Protocol |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ilexgenin A (0~100 μM; 24 hours; HT 29 and HCT 116 cells) effectively decreases cell viability in HT 29 and HCT 116 cells.PMID:32031354 Ilexgenin A (12.5~50 μM; 24 hours; HT 29 cells) downregulates the expression of SREBP-1, inhibits the translocation of SREBP-1 to the nucleus and decreases the content of TG. Ilexgenin A (12.5~50 μM; HT 29 and HCT 116 cells) induces cell cycle arrest at G1 phase in colon cancer cells. Ilexgenin A (12.5~50 μM; 24 hours; HCT 116 cells) modulates lipid metabolism. Ilexgenin A (50 μM; 24 hours; HT 29 and HCT 116 cells) regulates SREBP-1 by inhibiting HIF1α. Ilexgenin A inhibits fatty acids synthesis.|In Vivo:|Ilexgenin A (20 mg/kg) ameliorates the AOM/DSS induced carcinogenesis. Ilexgenin A can regulate lipid metabolism. Ilexgenin A decreases the expression of SREBP-1 and HIF 1α in AOM/DSS mice.|Products are for research use only. Not for human use.|