Product Name :
CN128 hydrochloride
Description:
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.
CAS:
1335282-05-7
Molecular Weight:
295.76
Formula:
C15H18ClNO3
Chemical Name:
3-hydroxy-1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-2-methyl-1,4-dihydropyridin-4-one; chlorohydrogen
Smiles :
Cl.CC1=C(O)C(=O)C=CN1[C@H](CC1C=CC=CC=1)CO
InChiKey:
CYFDKXLBMMEWNV-BTQNPOSSSA-N
InChi :
InChI=1S/C15H17NO3.ClH/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12;/h2-8,13,17,19H,9-10H2,1H3;1H/t13-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia.|Product information|CAS Number: 1335282-05-7|Molecular Weight: 295.76|Formula: C15H18ClNO3|Synonym:|CN328|Chemical Name: 3-hydroxy-1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-2-methyl-1,4-dihydropyridin-4-one; chlorohydrogen|Smiles: Cl.CC1=C(O)C(=O)C=CN1[C@H](CC1C=CC=CC=1)CO|InChiKey: CYFDKXLBMMEWNV-BTQNPOSSSA-N|InChi: InChI=1S/C15H17NO3.ClH/c1-11-15(19)14(18)7-8-16(11)13(10-17)9-12-5-3-2-4-6-12;/h2-8,13,17,19H,9-10H2,1H3;1H/t13-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 28.57 mg/mL (96.60 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.Lansoprazole site |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CN128 hydrochloride possesses a high selectivity for iron(III) over others metals.Collagenase, Type I MMP |In Vivo:|CN128 hydrochloride (450 μmol/kg; p.PMID:33274845 o.) exhibits a good iron scavenging efficacy in rat. The iron removal efficacies of CN128 displays a dose-dependent behavior. CN128 hydrochloride lacks genetic toxicity. CN128 hydrochloride (75 μmol/kg; i.g.) possesses good oral bioavailability (82.6%), high maximal plasma concentration, and low clearance rats after an oral dose of 75 μmol/kg. CN128 hydrochloride is well-tolerated, with no mortality being observed at the higher dose levels in rats.|References:|Wenteng Chen, et al. CN128: A New Orally Active Hydroxypyridinone Iron Chelator. J Med Chem. 2020 Apr 23;63(8):4215-4226.Products are for research use only. Not for human use.|