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PDI monoclonal antibody (1D3) (PE conjugate)
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The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing – and one domain lacking – a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities.{{872573-93-8} medchemexpress|{872573-93-8} Protocol|{872573-93-8} In Vitro|{872573-93-8} supplier} Platelet surface thiols and disulphides play an important role in platelet responses.{{1456858-57-3} site|{1456858-57-3} Protocol|{1456858-57-3} Formula|{1456858-57-3} supplier} Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.PMID:30969520 Flow cytometry analysis of 106 Jurkat cells stained using PDI mAb (1D3), R-Phycoerythrin Conjugate at a concentration of 10µg/ml. Flow cytometry analysis of 106 Jurkat cells stained using PDI mAb (1D3), R-Phycoerythrin Conjugate at a concentration of 10µg/ml.
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| Alternative Name P4HB, protein disulfide isomerase | Application Flow Cytometry | Application Notes Detects a band of ~58kDa by Western blot. | Clone 1D3 | Formulation Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. | Host Mouse | Immunogen Synthetic peptide corresponding to the sequence near the C-terminus of rat PDI. | Isotype IgG1 | Recommendation Dilutions/Conditions Flow Cytometry (1:100)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from ascites | Species Reactivity Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep, Xenopus | UniProt ID P04785 | Unit of Measure (UM) µg