Product Name :
RORγt agonist 1
Description:
RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC50 of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy.
CAS:
2377378-89-5
Molecular Weight:
545.45
Formula:
C24H17F6NO5S
Chemical Name:
2-{6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)benzenesulfonyl]-2,3-dihydro-1H-indol-2-yl}acetic acid
Smiles :
OC(=O)CC1CC2=CC=C(C=C2N1S(=O)(=O)C1=CC(=CC=C1)C(F)(F)F)C1=CC(F)=CC(=C1)OC(F)F
InChiKey:
UAFXMLYFRFORFY-UHFFFAOYSA-N
InChi :
InChI=1S/C24H17F6NO5S/c25-17-6-15(8-19(11-17)36-23(26)27)13-4-5-14-7-18(12-22(32)33)31(21(14)9-13)37(34,35)20-3-1-2-16(10-20)24(28,29)30/h1-6,8-11,18,23H,7,12H2,(H,32,33)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC50 of 20.{{Exendin-4} site|{Exendin-4} Agonist|{Exendin-4} TGF-beta/Smad|{Exendin-4} Biological Activity|{Exendin-4} In Vitro|{Exendin-4} manufacturer} 8 nM.{{IL-4 Protein, Human} web|{IL-4 Protein, Human} Purity & Documentation|{IL-4 Protein, Human} In stock|{IL-4 Protein, Human} supplier|{IL-4 Protein, Human} Epigenetics} RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile.PMID:33048602 RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy.|Product information|CAS Number: 2377378-89-5|Molecular Weight: 545.45|Formula: C24H17F6NO5S|Chemical Name: 2-{6-[3-(difluoromethoxy)-5-fluorophenyl]-1-[3-(trifluoromethyl)benzenesulfonyl]-2,3-dihydro-1H-indol-2-yl}acetic acid|Smiles: OC(=O)CC1CC2=CC=C(C=C2N1S(=O)(=O)C1=CC(=CC=C1)C(F)(F)F)C1=CC(F)=CC(=C1)OC(F)F|InChiKey: UAFXMLYFRFORFY-UHFFFAOYSA-N|InChi: InChI=1S/C24H17F6NO5S/c25-17-6-15(8-19(11-17)36-23(26)27)13-4-5-14-7-18(12-22(32)33)31(21(14)9-13)37(34,35)20-3-1-2-16(10-20)24(28,29)30/h1-6,8-11,18,23H,7,12H2,(H,32,33)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|RORγt agonist 1 shows high metabolic stability (t1/2 = 113 min) in mouse liver microsome and has improved aqueous solubility at pH 7.4.|Products are for research use only. Not for human use.|