Product Name :
DO-264
Description:
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.
CAS:
2301866-59-9
Molecular Weight:
558.40
Formula:
C23H20Cl2F3N5O2S
Chemical Name:
3-(1-{3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]pyridin-2-yl}piperidin-4-yl)-1-(pyridin-3-yl)thiourea
Smiles :
FC(F)(F)OC1=CC(Cl)=C(C=C1)OC1=CC=NC(=C1Cl)N1CCC(CC1)NC(=S)NC1=CN=CC=C1
InChiKey:
PIEQDBPBBQPLPL-UHFFFAOYSA-N
InChi :
InChI=1S/C23H20Cl2F3N5O2S/c24-17-12-16(35-23(26,27)28)3-4-18(17)34-19-5-9-30-21(20(19)25)33-10-6-14(7-11-33)31-22(36)32-15-2-1-8-29-13-15/h1-5,8-9,12-14H,6-7,10-11H2,(H2,31,32,36)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM.|Product information|CAS Number: 2301866-59-9|Molecular Weight: 558.40|Formula: C23H20Cl2F3N5O2S|Chemical Name: 3-(1-{3-chloro-4-[2-chloro-4-(trifluoromethoxy)phenoxy]pyridin-2-yl}piperidin-4-yl)-1-(pyridin-3-yl)thiourea|Smiles: FC(F)(F)OC1=CC(Cl)=C(C=C1)OC1=CC=NC(=C1Cl)N1CCC(CC1)NC(=S)NC1=CN=CC=C1|InChiKey: PIEQDBPBBQPLPL-UHFFFAOYSA-N|InChi: InChI=1S/C23H20Cl2F3N5O2S/c24-17-12-16(35-23(26,27)28)3-4-18(17)34-19-5-9-30-21(20(19)25)33-10-6-14(7-11-33)31-22(36)32-15-2-1-8-29-13-15/h1-5,8-9,12-14H,6-7,10-11H2,(H2,31,32,36)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (179.{{Methimazole} site|{Methimazole} Technical Information|{Methimazole} Purity|{Methimazole} custom synthesis|{Methimazole} Cancer} 08 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Finerenone} medchemexpress|{Finerenone} Mineralocorticoid Receptor|{Finerenone} Biological Activity|{Finerenone} In Vivo|{Finerenone} custom synthesis|{Finerenone} Cancer} |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DO-264 displays an IC50 value of 11 nM (9.6 nM-13 nM). DO-264 blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates (DO-264 IC50 values of ~30 and 90 nM against mouse and human ABHD12, respectively) and the ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain (IC50=2.PMID:23537004 8 nM, 2.4 nM-3.3 nM) and human THP-1 cells (IC50= 8.6 nM, 6.3 nM-12 nM).|In Vivo:|Mice treated with DO-264 display dose-dependent increases in brain lyso-PS and 20:4 PS content that are qualitatively similar to the changes observed in ABHD12–/– mice. DO-264-treated mice, however, show minimal impairment in auditory function following four weeks of drug exposure. Both ABHD12–/– and DO-264-treated mice display exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death.|Products are for research use only. Not for human use.|