Product Name :
Germicidin B
Description:
Germicidin is a pyranone antibiotic originally excreted by Streptomyces viridochromogenes NRRL B-1551. Germicidin has an inhibitory effect on the germination of its own arthrospores at a concentration as low as 200 pM (40 pg/ml). Higher concentrations of germicidin inhibited porcine Na+/K+-activated ATPase and retarded the germination of the cress Lepidium sativum with an ID50 of 100 μM. Germicidin was the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from the supernatant of the submerged culture . Germicidins B inhibited germination of S. coelicolor A3(2) spores above 1 μg/ml. The S. coelicolor A3(2) spores collected from a single petri dish (9 cm i.d.) contained 5.4 μg of germicidin A (~2.7 × 10-14 g per spore) and contents of germicidins B, C and D were 0.2–0.8 μg. The activity of the spore extract corresponded well with the sum of the activity of each germicidin. Germicidins functioned as self-germination inhibitors in S. coelicolor A3(2) .
CAS:
150973-78-7
Molecular Weight:
182.22
Formula:
C10H14O3
Chemical Name:
3-ethyl-4-hydroxy-6-(propan-2-yl)-2H-pyran-2-one
Smiles :
CCC1=C(O)C=C(OC1=O)C(C)C
InChiKey:
SZBDLUWYHDLLAG-UHFFFAOYSA-N
InChi :
InChI=1S/C10H14O3/c1-4-7-8(11)5-9(6(2)3)13-10(7)12/h5-6,11H,4H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Germicidin is a pyranone antibiotic originally excreted by Streptomyces viridochromogenes NRRL B-1551. Germicidin has an inhibitory effect on the germination of its own arthrospores at a concentration as low as 200 pM (40 pg/ml).{{PCI-34051} web|{PCI-34051} Cell Cycle/DNA Damage|{PCI-34051} NF-κB|{PCI-34051} Technical Information|{PCI-34051} Description|{PCI-34051} manufacturer} Higher concentrations of germicidin inhibited porcine Na+/K+-activated ATPase and retarded the germination of the cress Lepidium sativum with an ID50 of 100 μM.{{TMPA} MedChemExpress|{TMPA} Nuclear Hormone Receptor 4A/NR4A|{TMPA} Protocol|{TMPA} Formula|{TMPA} supplier|{TMPA} Autophagy} Germicidin was the first known autoregulative inhibitor of spore germination in the genus Streptomyces and was isolated from the supernatant of germinated spores, but also from the supernatant of the submerged culture .PMID:23795974 Germicidins B inhibited germination of S. coelicolor A3(2) spores above 1 μg/ml. The S. coelicolor A3(2) spores collected from a single petri dish (9 cm i.d.) contained 5.4 μg of germicidin A (~2.7 × 10-14 g per spore) and contents of germicidins B, C and D were 0.2–0.8 μg. The activity of the spore extract corresponded well with the sum of the activity of each germicidin. Germicidins functioned as self-germination inhibitors in S. coelicolor A3(2) .|Product information|CAS Number: 150973-78-7|Molecular Weight: 182.22|Formula: C10H14O3|Chemical Name: 3-ethyl-4-hydroxy-6-(propan-2-yl)-2H-pyran-2-one|Smiles: CCC1=C(O)C=C(OC1=O)C(C)C|InChiKey: SZBDLUWYHDLLAG-UHFFFAOYSA-N|InChi: InChI=1S/C10H14O3/c1-4-7-8(11)5-9(6(2)3)13-10(7)12/h5-6,11H,4H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|