Product Name :
Valproic acid
Description:
AI-10-49 is an inhibitor that binds the transcription factor fusion CBFβ-SMMHC. AI-10-49, that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1. AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML, and they provide support for transcription factor targeted therapy in other cancers.
CAS:
99-66-1
Molecular Weight:
144.21
Formula:
C8H16O2
Chemical Name:
2-propylpentanoic acid
Smiles :
CCCC(CCC)C(O)=O
InChiKey:
NIJJYAXOARWZEE-UHFFFAOYSA-N
InChi :
InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tralokinumab} web|{Tralokinumab} Interleukin Related|{Tralokinumab} Protocol|{Tralokinumab} In stock|{Tralokinumab} custom synthesis|{Tralokinumab} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.{{Nifedipine} site|{Nifedipine} Autophagy|{Nifedipine} Biological Activity|{Nifedipine} Formula|{Nifedipine} custom synthesis|{Nifedipine} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23290930
Additional information:
AI-10-49 is an inhibitor that binds the transcription factor fusion CBFβ-SMMHC. AI-10-49, that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1. AI-10-49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death. These data suggest that direct inhibition of the oncogenic CBFβ-SMMHC fusion protein may be an effective therapeutic approach for inv(16) AML, and they provide support for transcription factor targeted therapy in other cancers.|Product information|CAS Number: 99-66-1|Molecular Weight: 144.21|Formula: C8H16O2|Chemical Name: 2-propylpentanoic acid|Smiles: CCCC(CCC)C(O)=O|InChiKey: NIJJYAXOARWZEE-UHFFFAOYSA-N|InChi: InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|