Product Name :
Lp-PLA2-IN-2
Description:
Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.
CAS:
2071636-15-0
Molecular Weight:
394.46
Formula:
C19H23FN2O4S
Chemical Name:
2-fluoro-5-{2-[(4S)-4-(4-methyl-1,1-dioxo-1λ⁶-thian-4-yl)-2-oxopyrrolidin-1-yl]ethoxy}benzonitrile
Smiles :
CC1(CCS(=O)(=O)CC1)[C@@H]1CC(=O)N(C1)CCOC1=CC(C#N)=C(F)C=C1
InChiKey:
SYEMWCXBADSSGE-OAHLLOKOSA-N
InChi :
InChI=1S/C19H23FN2O4S/c1-19(4-8-27(24,25)9-5-19)15-11-18(23)22(13-15)6-7-26-16-2-3-17(20)14(10-16)12-21/h2-3,10,15H,4-9,11,13H2,1H3/t15-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.|Product information|CAS Number: 2071636-15-0|Molecular Weight: 394.46|Formula: C19H23FN2O4S|Chemical Name: 2-fluoro-5-{2-[(4S)-4-(4-methyl-1,1-dioxo-1λ⁶-thian-4-yl)-2-oxopyrrolidin-1-yl]ethoxy}benzonitrile|Smiles: CC1(CCS(=O)(=O)CC1)[C@@H]1CC(=O)N(C1)CCOC1=CC(C#N)=C(F)C=C1|InChiKey: SYEMWCXBADSSGE-OAHLLOKOSA-N|InChi: InChI=1S/C19H23FN2O4S/c1-19(4-8-27(24,25)9-5-19)15-11-18(23)22(13-15)6-7-26-16-2-3-17(20)14(10-16)12-21/h2-3,10,15H,4-9,11,13H2,1H3/t15-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Clobenpropit} MedChemExpress|{Clobenpropit} Immunology/Inflammation|{Clobenpropit} Purity & Documentation|{Clobenpropit} Formula|{Clobenpropit} custom synthesis|{Clobenpropit} Cancer} |Shelf Life: ≥12 months if stored properly.{{Inotuzumab} site|{Inotuzumab} ADC Antibody|{Inotuzumab} Purity & Documentation|{Inotuzumab} Description|{Inotuzumab} manufacturer|{Inotuzumab} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23695992 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with an IC50 of 62 nM in PED6 assay.|In Vivo:|Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively.|Products are for research use only. Not for human use.|