Product Name :
PD 404182
Description:
PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.
CAS:
72596-74-8
Molecular Weight:
217.29
Formula:
C11H11N3S
Chemical Name:
9-thia-3,7-diazatricyclo[8.4.0.0²,⁷]tetradeca-1(14),2,10,12-tetraen-8-imine
Smiles :
N=C1SC2=CC=CC=C2C2=NCCCN21
InChiKey:
JNENSSREQFBZGT-UHFFFAOYSA-N
InChi :
InChI=1S/C11H11N3S/c12-11-14-7-3-6-13-10(14)8-4-1-2-5-9(8)15-11/h1-2,4-5,12H,3,6-7H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM.{{Eculizumab} site|{Eculizumab} Immunology/Inflammation|{Eculizumab} Protocol|{Eculizumab} In Vitro|{Eculizumab} manufacturer|{Eculizumab} Autophagy} PD 404182 exhibits antiangiogenic and antiviral activity in vitro.|Product information|CAS Number: 72596-74-8|Molecular Weight: 217.29|Formula: C11H11N3S|Chemical Name: 9-thia-3,7-diazatricyclo[8.4.0.0²,⁷]tetradeca-1(14),2,10,12-tetraen-8-imine|Smiles: N=C1SC2=CC=CC=C2C2=NCCCN21|InChiKey: JNENSSREQFBZGT-UHFFFAOYSA-N|InChi: InChI=1S/C11H11N3S/c12-11-14-7-3-6-13-10(14)8-4-1-2-5-9(8)15-11/h1-2,4-5,12H,3,6-7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (230.11 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Hesperetin} MedChemExpress|{Hesperetin} p38 MAPK|{Hesperetin} Purity & Documentation|{Hesperetin} In Vitro|{Hesperetin} supplier|{Hesperetin} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:23341580 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs. PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity. PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM. PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora.|Products are for research use only. Not for human use.|