Product Name :
Bay 36-7620
Description:
Metabotropic glutamate (mGlu) receptors are G proteincoupled receptors (GPCRs) that act predominantly as modulators of synaptic transmission. As such, they play a role in many physiological and pathophysiological processes. BAY36-7620 is a pPotent non-competitive mGlu1 receptor antagonist with. In vitro: BAY36-7620 is a potent and selective antagonist at mGlu1receptors and inhibits >60% of mGlu1a receptor constitutive activity (IC50 = 0.38 μM). BAY36-7620 is thus the first described mGlu1 receptor inverse agonist. Moreover, BAY36-7620 did not displace the [3H]quisqualate binding from the Glu-binding pocket, indicating that BAY36-7620 is a noncompetitive mGlu1 antagonist . In vivo: BAY 36-7620 protected against pentylenetetrazole-induced convulsions in the mouse. As assessed in rats, BAY 36-7620 was devoid of the typical side effects of the ionotropic glutamate (iGlu) receptor antagonists phencyclidine and MK-801. Therefore, BAY 36-7620 did not disrupt sensorimotor gating, induce phencyclidine-like discriminative effects or stereotypical behavior, or facilitate intracranial self-stimulated behavior . Clinical trial: Up to now, BAY 36-7620 is still in the preclinical development stage.
CAS:
232605-26-4
Molecular Weight:
278.35
Formula:
C19H18O2
Chemical Name:
(3aS,6aS)-5-methylidene-6a-[(naphthalen-2-yl)methyl]-hexahydro-1H-cyclopenta[c]furan-1-one
Smiles :
C=C1C[C@]2(CC3C=CC4C=CC=CC=4C=3)[C@@H](COC2=O)C1
InChiKey:
CVIRWLJKDBYYOG-MJGOQNOKSA-N
InChi :
InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Metabotropic glutamate (mGlu) receptors are G proteincoupled receptors (GPCRs) that act predominantly as modulators of synaptic transmission. As such, they play a role in many physiological and pathophysiological processes. BAY36-7620 is a pPotent non-competitive mGlu1 receptor antagonist with. In vitro: BAY36-7620 is a potent and selective antagonist at mGlu1receptors and inhibits >60% of mGlu1a receptor constitutive activity (IC50 = 0.38 μM). BAY36-7620 is thus the first described mGlu1 receptor inverse agonist. Moreover, BAY36-7620 did not displace the [3H]quisqualate binding from the Glu-binding pocket, indicating that BAY36-7620 is a noncompetitive mGlu1 antagonist .{{Dexamethasone} medchemexpress|{Dexamethasone} Autophagy|{Dexamethasone} Technical Information|{Dexamethasone} Formula|{Dexamethasone} supplier|{Dexamethasone} Autophagy} In vivo: BAY 36-7620 protected against pentylenetetrazole-induced convulsions in the mouse.{{Tenofovir} site|{Tenofovir} Anti-infection|{Tenofovir} Protocol|{Tenofovir} References|{Tenofovir} custom synthesis|{Tenofovir} Cancer} As assessed in rats, BAY 36-7620 was devoid of the typical side effects of the ionotropic glutamate (iGlu) receptor antagonists phencyclidine and MK-801.PMID:23710097 Therefore, BAY 36-7620 did not disrupt sensorimotor gating, induce phencyclidine-like discriminative effects or stereotypical behavior, or facilitate intracranial self-stimulated behavior . Clinical trial: Up to now, BAY 36-7620 is still in the preclinical development stage.|Product information|CAS Number: 232605-26-4|Molecular Weight: 278.35|Formula: C19H18O2|Chemical Name: (3aS,6aS)-5-methylidene-6a-[(naphthalen-2-yl)methyl]-hexahydro-1H-cyclopenta[c]furan-1-one|Smiles: C=C1C[C@]2(CC3C=CC4C=CC=CC=4C=3)[C@@H](COC2=O)C1|InChiKey: CVIRWLJKDBYYOG-MJGOQNOKSA-N|InChi: InChI=1S/C19H18O2/c1-13-8-17-12-21-18(20)19(17,10-13)11-14-6-7-15-4-2-3-5-16(15)9-14/h2-7,9,17H,1,8,10-12H2/t17-,19+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|