Ncers. Even so, its use is limited as a result of lethal effects of radiation on standard tissues.[1] Thus, attempts had been made earlier to improve the therapeutic effect of radiotherapy by keeping the normal tissue damage to acceptable level by utilizing synthetic compounds like cysteine, cysteamine, and WR-2721.[2] Having said that, the thriving use ofAddress for correspondence:Dr. Shrikant L. Patil, Division of Physiology, K.S. Hegde Healthcare Academy, Nitte University, Mangalore, Karnataka, India. E-mail: shrikantlpatil@gmail Access this short article onlineQuick Response Code:these radioprotectors in medical practice just isn’t appreciated significantly due to their inherent systemic toxicity and their biological brief half life. As a result, the quest for successful, nontoxic compound with its optimal radioprotective capability is of quick require that shifted the interest more around the naturally occurring dietary antioxidants. Quite a few dietary antioxidants, medicinal plant extracts, and their isolated constituents happen to be reported for their hepatoprotective, neuroprotective, anti-inflammatory, and also antioxidant or radical scavenging properties.[2-4] Various earlier research on several of the medicinal plants[5-8] indicated the usefulness of those organic merchandise in reducing the radiation-induced genotoxicity and animal mortality. Oxidative tension and low antioxidant levels are implicated within the etiology of an inflammatory disease. Rutin (RUT) and quercetin (QRT) is potent dietary antioxidants, which had been also found to display anti-inflammatory activities. Rutin has been shown to possess antioxidant and anti-inflammatory actions.[9] Natural non-toxic bioflavonoid rutin (vitamin P) inhibited oxygen radical overproduction in both rheumatoid arthritis and Fanconi anemia in an equally efficient manner and for that reason can be thought of as a helpful supportingJournal of Medical Physics, Vol.Withaferin A 38, No.Dimethyl sulfoxide two, 87-92,Web page: www.PMID:34856019 jmp.org.inDOI: 10.4103/0971-6203.Patil, et al.: Radioprotection by rutin and quercetinpharmaceutical agent for the remedy of no cost radical pathologies.[10] The oxidative effects of ultraviolet A (UVA) light (320-400 nm) and also the antioxidant effects of QRT had been examined in rat blood. Exposure of rats to UVA light results in oxidative pressure reflected by increased MDA and lowered antioxidant enzyme levels. The administration of QRT appeared to become a valuable strategy to reduce the harm made by UVA radiation.[11] The present study was undertaken to assess the effect of RUT and QRT provided as a protective regimen against radiation-induced oxidative strain, assessed by alteration in intracellular antioxidant enzymes, lipid peroxidation (LPO), as well as in vitro free of charge radical quenching.designed well-ventilated acrylic box and exposed to whole-body radiation from 60Co gamma tele-therapy facility (Theratron Atomic Power Agency, Canada) at the Shirdi Sai Baba Cancer Hospital, Manipal, at a dose rate of 1.33 Gy/min and supply to surface distance of 61 cm. Estimation of liver antioxidant enzymes To know the mechanism of radioprotection, biochemical estimations were carried out. Animals had been divided into groups of six animals every as follows: 1. Untreated Manage group: The animals of this group had been administered 0.1 ml/kg bw of CMC orally for five consecutive days. 2. RUT and QRT alone group: The animals of this group were administered optimum dose of RUT (10 mg/kg bw) and QRT (20 mg/kg bw) orally for 5 consecutive days. three. Radiation alone group: These animals have been.