nuscript. Funding The BIGPIC trial is supported by the National Heart, Lung, and Blood Institute on the National Institutes of Overall health below award quantity 5R01HL125487. The content material is solely the duty in the authors and will not necessarily represent the official views from the National Institutes of Health. Samuel Ruchman was supported by the American Heart Association 2017 Student Scholarship in Cardiovascular Illness. Competing interests None declared. Patient consent for publication Not expected. Ethics approval The BIGPIC trial is approved by the Institutional CCR8 Agonist MedChemExpress overview Boards at the Icahn College of Medicine at Mount Sinai and the NYU Grossman School of Medicine, each in New York, NY, and by the Institutional Study and Ethics Committee at Moi University, Eldoret, Kenya. Provenance and peer overview Not commissioned; externally peer reviewed. Information availability statement Information are offered upon reasonable request. Information are going to be made out there upon reasonable request towards the corresponding author and approval by the AMPATH Investigation System. Supplemental material This content material has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and might not happen to be peer-reviewed. Any opinions or recommendations discussed are solely those with the author(s) and are usually not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Exactly where the content material involves any translated material, BMJ will not warrant the accuracy and reliability with the translations (such as but not restricted to neighborhood regulations, clinical guidelines, terminology, drug names and drug dosages), and just isn’t accountable for any error and/or omissions arising from translation and adaptation or otherwise. Open access That is an open access report distributed in accordance with all the Inventive Commons Attribution Non Commercial (CC BY-NC four.0) license, which permits others to distribute, remix, adapt, build upon this operate non-commercially, and license their derivative operates on distinctive terms, offered the original perform is adequately cited, appropriate credit is provided, any alterations produced indicated, as well as the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. ORCID iDs Samuel G Ruchman http://orcid.org/0000-0002-1950-0924 Allison K Delong http://orcid.org/0000-0001-8660-8073 Rajesh Vedanthan http://orcid.org/0000-0001-7138-9 Robalino JD, Macy M. Peer IL-5 Antagonist web effects on adolescent smoking: are popular teens much more influential PLoS 1 2018;13:e0189360. ten Campbell R, Starkey F, Holliday J, et al. An informal school-based peer-led intervention for smoking prevention in adolescence (assist): a cluster randomised trial. Lancet 2008;371:159502. 11 Moore S, Salsberg J, Leroux J. Advancing social capital interventions from a network and population overall health viewpoint. In: Kawachi I, Takao S, Subramanian SV, eds. Worldwide perspectives on social capital and health. New York, NY: Springer, 2013: 18903. 12 Centola D. An experimental study of homophily inside the adoption of wellness behavior. Science 2011;334:12692. 13 Modest ML. Weak ties plus the core discussion network: why people today routinely discuss essential matters with unimportant alters. Soc Networks 2013;35:4703. 14 Hurlbert JS, Haines VA, Beggs JJ. Core networks and tie activation: what types of routine networks allocate resources in nonroutine circumstances Am Sociol Rev 2000;65:59818. 15 Perry BL, Pescosolido BA, Borgatti SP. Egocentric network evaluation: founda