T cell differentiation, maturation, or proliferation, but Wnt-3a activates mature mast cells to generate the chemokines IL-8 and CCL8. This activation could contribute towards the recruitment of immune cells in situations related with elevated Wnt-3a expression, including asthma. Inhibitors targeting Wnt signaling is below evaluation for the IFN-alpha 14 Proteins custom synthesis therapy of idiopathicCells 2019, 8,13 ofpulmonary fibrosis [30]. Our outcomes and current findings linking Wnt signaling to asthma point to the possibility that asthma individuals could also benefit from such inhibitors [31]. Nevertheless, thinking of the many functions of Wnt signaling, caution needs to be taken when targeting this pathway.Supplementary Components: The following are available on the net at http://www.mdpi.com/2073-4409/8/11/1372/s1: Figure S1A: Expression of FZDs in human lung mast cells; Figure S1B: Expression co-receptors in human lung mast cells; Figure S1C: Expression of Wnts inn human lung mast cells; Figure S1D: Expression of Wnts in human lung tissue; Figure S1E: Expression of FZDs in human skin mast cells; Figure S2: Olink screen of released cytokines. Author Contributions: Conceptualization, E.R. and G.N.; methodology, E.R.; validation, J.T., J.E.L., and E.R.; formal evaluation, J.T., J.E.L., and E.R.; investigation, J.T., J.E.L., and E.R.; sources, J.S. and G.S.; writing–original draft preparation, E.R. and J.T.; writing–review and