D SP600125MedChemExpress SP600125 whether BIS monitoring is an alternative method or not. Materials
D whether BIS monitoring is an alternative method or not. Materials and methods Thirteen patients received in the ICU with deep coma between February 2004 and September 2004 were included in the study. GCS was 5 for all patients during ICU admittance. The reasons for coma were intracranial hemorrhagia, head trauma, cerebral anoxia. After the clinical diagnosis of brain death was made, all patients underwent EEG monitoring. Clinical inspection and EEG were made twice for 24 hours, BIS monitoring was performed for 2 hours after the detection of brain death. Results BIS values were 0 for 12 patients and 5 for one patient. Bioelectric silence was detected in all EEGs of all patients. Discussion BIS, which depends on bispectral analysis of EEG parameters, is used in the ICU for evaluation of sedation level. A meaningful correlation between neurologic status GCS and BIS has been reported for coma patients without sedation. Our findings are in line with these studies. BIS seems to be an alternative method for diagnosis of brain death with the advantage of easy application. However, EMG activity and cardiovascular hyperpulsatility may cause artifacts and false BIS evaluations. We believe that more studies are necessary for routine application of this new method.8 ?1.0* 16 ?0.4 21 ?8 14 ?1.1 17 ?0.9 20 43 6.Data presented as mean ?SEM. *P < 0.05 compared with NHBD and CONT.Conclusions ALC during isolated reperfusion is decreased following brain death in HBD but not in NHBD. The effect of terbutaline on ALC was mostly apparent in HBD. These data further support the use of NHBD in lung transplantation. Terbutaline may be a promising tool to stimulate epithelial function in lungs from HBD and to resolve ischemia-reperfusion injury.P470 Older age, female sex, and increased IL-6 decrease the organ yield from cadaveric donorsM Raghavan1, R Venkataraman1, A Wahed2, M Carter1, M Elder1, G Hergenroeder3, D Powner3, J Kellum1 1University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2University of Pittsburgh, PA, USA; 3University of Texas Health Science Center, Houston, TX, USA Critical Care 2006, 10(Suppl 1):P470 (doi: 10.1186/cc4817) Introduction A variety of factors are believed to impact the number of organs explanted for transplantation in cadaveric organ donors, including age, stability of the patient and existing co-morbidities. Brain-death-induced systemic inflammation could also adversely affect the number of organs explanted for transplantation. Hence, in this observational study we sought to examine the various factors including the inflammatory response that occur in cadaveric organ donors and to determine their relative impact on organ explantation. Methods We enrolled 30 cadaveric organ donors in this prospective observational, two-center study. After obtaining PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25962748 informed consent, we collected clinical information including demographics, cause of death and donor management details. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27196668 We measured plasma IL-6 levels at baseline and hourly for the first 4 hours after brain death and immediately before organ explantation. We analyzed the association between the number of organs explanted and clinical, demographic and immunologic variables by univariate and multivariable regression. Finally, we repeated our analysis on donors younger than 50 years of age. Results The number of organs explanted from patients ranged from 0 to 7, with an average of about three organs per patient. In multivariable analysis, older age and female sex were the only var.