tion was 8.164.8 drugs. Polydrug therapy was seen in 74.1% of all the admissions and 83.9% of polydrug-therapy-treated patients were elderly. compared to dutasteride, whereas the combination of dutasteride and finasteride was used only in one hospital admission. Other Concurrent Medications Drug Treatments Used in BPH Patients DRPs in BPH Patients A total number of 390 DRPs were identified in this study. There was an average of 1.561.3 problems and 1.161.0 causes of DRPs per PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19651758 hospital admission. 197 cases of hospitalization were Drug-Related Problems detected, with at least one clinically relevant DRP, and a maximum of six DRPs in any single patient. The top three categories of DRPs encountered were drug choice problems, drug interactions, and dosing problems as shown in including both hematoma and hematuria. In our study, aspirin was associated with one case of anaphylaxis. Other drug classes we examined such as antibiotics, anticoagulants, analgesics, and psychotropic agents were also reported to cause adverse reactions in this study. Drug Choice Problems As shown in Adverse Reactions A total of 31 adverse reactions involving non-allergic, allergic, and toxic effect reactions to the drugs were identified. Of these, a-blockers such as alfuzosin, doxazosin and tamsulosin that were prescribed to treat BPH were implicated in three cases of postural hypotension. Antidiabetic agents such as insulin and sulphonylureas were associated with six cases of hypoglycemia in this study. In contrast, antihypertensive agents such as perindopril, hydrochlorothiazide, and spironolactone were associated with three cases of adverse reactions, which were 1 case of persistent dry cough, 1 case of hyponatremia, and 1 case of gynaecomastia. Besides that, there were cases where persistently high blood pressure was left unattended, there was untreated pedal edema, and aspirin was not given as a secondary prophylaxis in patients with a high risk of recurrent stroke. On the other hand, 34 cases of drug choice problems involving the use of drugs without clear indications were recorded. These included the use of gastro-protective agents such as omeprazole and ranitidine for stress ulcer prophylaxis when there was no clear indication and the prescription of metoclopramide to prevent emesis when there was no active complaint from patients. Drug Use Problems There were a total of 20 drug use problems that were identified in this study. BPH medication was implicated in nine cases of drug use problems in this study. It was reported that patients were not adhered to doxazosin and dutasteride in eight cases and one case of hospital admissions respectively. Also, antidiabetic agents such as gliclazide and insulin, antihypertensive agents such as prazosin and diuretics, antiplatelets including aspirin and ticlopidine as well as the other medications such as statins, allopurinol, and antibiotics were found to be associated with non-compliance of medications. Drug Interactions Among the 390 DRPs identified, approximately 25% of that was caused by potential drug-drug interactions.a-blockers that were used for the treatment of BPH were involved in more than half of all the drug interactions. The drug pairs that were most commonly to be associated with drug interactions were doxazosin and 
amlodipine, alfuzosin and amlodipine, simvastatin and amlodipine, where simvastatin was prescribed at a dose STA 4783 web greater than 20 mg/day, aspirin and clopidogrel, as well as the other interactions, a