Lp-PLA2-IN-2

Product Name : Lp-PLA2-IN-2Description:Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.CAS: 2071636-15-0Molecular Weight:394.46Formula: C19H23FN2O4SChemical Name: 2-fluoro-5-{2-ethoxy}benzonitrileSmiles :…

VU0810464

Product Name : VU0810464Description:VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels…

Acoramidis

Product Name : AcoramidisDescription:Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis.CAS: 1446711-81-4Molecular Weight:292.31Formula:…

Azido-PEG2-CH2COOH

Product Name : Azido-PEG2-CH2COOHDescription:Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 882518-90-3Molecular Weight:189.17Formula: C6H11N3O4Chemical Name: 2-acetic acidSmiles : ==NCCOCCOCC(O)=OInChiKey: OCIIYNXOTJRSHW-UHFFFAOYSA-NInChi : InChI=1S/C6H11N3O4/c7-9-8-1-2-12-3-4-13-5-6(10)11/h1-5H2,(H,10,11)Purity: ≥98% (or…

Tri-(PEG1-C2-acid)

Product Name : Tri-(PEG1-C2-acid)Description:Tri-(PEG1-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.CAS: 1381861-95-5Molecular Weight:365.38Formula: C15H27NO9Chemical Name: 3-(2-{bisamino}ethoxy)propanoic acidSmiles : OC(=O)CCOCCN(CCOCCC(O)=O)CCOCCC(O)=OInChiKey: QNHMUDRSUKYNFE-UHFFFAOYSA-NInChi : InChI=1S/C15H27NO9/c17-13(18)1-7-23-10-4-16(5-11-24-8-2-14(19)20)6-12-25-9-3-15(21)22/h1-12H2,(H,17,18)(H,19,20)(H,21,22)Purity: ≥98%…

MS4077

Product Name : MS4077Description:MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) with a Kd of 37 nM for binding affinity to ALK.CAS: 2230077-10-6Molecular Weight:1134.73Formula: C55H72ClN9O13SChemical Name: 2-(4-{4-amino}pyrimidin-2-yl)amino]-2-methyl-5-(propan-2-yloxy)phenyl}piperidin-1-yl)-N-(17-{amino}-3,6,9,12,15-pentaoxaheptadecan-1-yl)acetamideSmiles : CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(=O)C(C)C)=C(Cl)C=N2)=C(C=C1C1CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1)OC(C)CInChiKey: VEKJQNCZEPLNJF-UHFFFAOYSA-NInChi…

Terbufibrol

Product Name : TerbufibrolDescription:Terbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat.CAS: 56488-59-6Molecular Weight:344.40Formula: C20H24O5Chemical Name: 4-benzoic acidSmiles :…

Tenacissoside G

Product Name : Tenacissoside GDescription:Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells.CAS: 191729-43-8Molecular Weight:792.95Formula: C42H64O14Chemical…

Trifludimoxazin

Product Name : TrifludimoxazinDescription:Trifludimoxazin is a protoporphyrinogen oxidase inhibiting (PPO) herbicide.CAS: 1258836-72-4Molecular Weight:412.34Formula: C16H11F3N4O4SChemical Name: 1,5-dimethyl-6-sulfanylidene-3--1,3,5-triazinane-2,4-dioneSmiles : CN1C(=S)N(C)C(=O)N(C2=CC3=C(C=C2F)OC(F)(F)C(=O)N3CC#C)C1=OInChiKey: AZHZOGYUMMIAOF-UHFFFAOYSA-NInChi : InChI=1S/C16H11F3N4O4S/c1-4-5-22-10-7-9(8(17)6-11(10)27-16(18,19)12(22)24)23-13(25)20(2)15(28)21(3)14(23)26/h1,6-7H,5H2,2-3H3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition:…

Lithospermoside

Product Name : LithospermosideDescription:Lithospermoside (Griffonin) is a nature product isolated from the stem bark of Ochna schweinfurthiana F. Hoffm.CAS: 63492-69-3Molecular Weight:329.30Formula: C14H19NO8Chemical Name: 2-oxy}cyclohex-2-en-1-ylidene]acetonitrileSmiles : N#C/C=C1/C=C(O)(O)/1O1O(CO)(O)(O)1OInChiKey: WIIDBJNWXCWLKF-VVAXPEBGSA-NInChi : InChI=1S/C14H19NO8/c15-4-3-6-1-2-7(17)9(18)13(6)23-14-12(21)11(20)10(19)8(5-16)22-14/h1-3,7-14,16-21H,5H2/b6-3-/t7-,8-,9+,10-,11+,12-,13+,14+/m1/s1Purity: ≥98%…

S-8921

Product Name : S-8921Description:S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.CAS: 151165-96-7Molecular Weight:540.60Formula: C30H36O9Chemical Name: methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylpentanoyl)-4-hydroxy-6,7,8-trimethoxynaphthalene-2-carboxylateSmiles : COC(=O)C1=C(C2=C(OC)C(OC)=C(C=C2C(O)=C1C(=O)CC(CC)CC)OC)C1=CC(OC)=C(C=C1)OCInChiKey: QEJQEIIPZKQCNP-UHFFFAOYSA-NInChi : InChI=1S/C30H36O9/c1-9-16(10-2)13-19(31)25-26(30(33)39-8)23(17-11-12-20(34-3)21(14-17)35-4)24-18(27(25)32)15-22(36-5)28(37-6)29(24)38-7/h11-12,14-16,32H,9-10,13H2,1-8H3Purity: ≥98% (or refer to the Certificate of…

ALD-PEG4-OPFP

Product Name : ALD-PEG4-OPFPDescription:ALD-PEG4-OPFP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).CAS: 1324007-10-4Molecular Weight:563.47Formula: C25H26F5NO8Chemical Name: 2,3,4,5,6-pentafluorophenyl 1--3,6,9,12-tetraoxapentadecan-15-oateSmiles : O=CC1C=CC(=CC=1)C(=O)NCCOCCOCCOCCOCCC(=O)OC1C(F)=C(F)C(F)=C(F)C=1FInChiKey: NHBPGMASABKYSZ-UHFFFAOYSA-NInChi :…

5-Acetyl-d3-amino-6-formylamino-3-methyluracil

Product Name : 5-Acetyl-d3-amino-6-formylamino-3-methyluracilDescription:Product informationCAS: 1185082-65-8Molecular Weight:229.21Formula: C8H10N4O4Chemical Name: N-(6-formamido-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(²H₃)acetamideSmiles : C()()C(=O)NC1=C(NC=O)NC(=O)N(C)C1=OInChiKey: RDZNZFGKEVDNPK-FIBGUPNXSA-NInChi : InChI=1S/C8H10N4O4/c1-4(14)10-5-6(9-3-13)11-8(16)12(2)7(5)15/h3H,1-2H3,(H,9,13)(H,10,14)(H,11,16)/i1D3Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-hazardous…

Acid-PEG4-mono-methyl ester

Product Name : Acid-PEG4-mono-methyl esterDescription:Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.CAS: 2028284-75-3Molecular Weight:308.32Formula: C13H24O8Chemical Name: 16-methoxy-16-oxo-4,7,10,13-tetraoxahexadecanoic acidSmiles : COC(=O)CCOCCOCCOCCOCCC(O)=OInChiKey: MOGNNSWXCSXEEM-UHFFFAOYSA-NInChi…

NBOH-2C-CN hydrochloride

Product Name : NBOH-2C-CN hydrochlorideDescription:Product informationCAS: 1539266-32-4Molecular Weight:348.82Formula: C18H21ClN2O3Chemical Name: 4-(2-{amino}ethyl)-2,5-dimethoxybenzonitrile hydrochlorideSmiles : Cl.COC1=CC(C#N)=C(C=C1CCNCC1=CC=CC=C1O)OCInChiKey: JQVAEIIIMVMJBO-UHFFFAOYSA-NInChi : InChI=1S/C18H20N2O3.ClH/c1-22-17-10-15(11-19)18(23-2)9-13(17)7-8-20-12-14-5-3-4-6-16(14)21;/h3-6,9-10,20-21H,7-8,12H2,1-2H3;1HPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature…

ZAPA sulfate

Product Name : ZAPA sulfateDescription:Product informationCAS: 371962-01-5Molecular Weight:244.25Formula: C4H8N2O6S2Chemical Name: (2Z)-3-(carbamimidoylsulfanyl)prop-2-enoic acid; sulfuric acidSmiles : NC(=N)S/C=C\C(O)=O.OS(O)(=O)=OInChiKey: UWVNHPNVOMFDHW-ODZAUARKSA-NInChi : InChI=1S/C4H6N2O2S.H2O4S/c5-4(6)9-2-1-3(7)8;1-5(2,3)4/h1-2H,(H3,5,6)(H,7,8);(H2,1,2,3,4)/b2-1-;Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under…

(±)-AC 7954 hydrochloride

Product Name : (±)-AC 7954 hydrochlorideDescription:Product informationCAS: 477313-09-0Molecular Weight:366.28Formula: C19H21Cl2NO2Chemical Name: (3R)-3-(4-chlorophenyl)-3--3,4-dihydro-1H-2-benzopyran-1-one hydrochlorideSmiles : Cl.CN(C)CC1(CC2=CC=CC=C2C(=O)O1)C1C=CC(Cl)=CC=1InChiKey: AJPGLOWFIBOGMH-FYZYNONXSA-NInChi : InChI=1S/C19H20ClNO2.ClH/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19;/h3-10H,11-13H2,1-2H3;1H/t19-;/m0./s1Purity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient…

Fumonisin B1, 96%

Product Name : Fumonisin B1, 96%Synonym: IUPAC Name : (2S)-2-(2-{oxy}-11,16,18-trihydroxy-5,9-dimethylicosan-7-yl]oxy}-2-oxoethyl)butanedioic acidCAS NO.:116355-83-0Molecular Weight : Molecular formula: C34H59NO15Smiles: CCCC(C)(OC(=O)C(CC(O)=O)C(O)=O)(C(C)C(O)CCCC(O)C(O)(C)N)OC(=O)C(CC(O)=O)C(O)=ODescription: Schisandrin RI-1 PMID:26446225

Triphosgene, 98%

Product Name : Triphosgene, 98%Synonym: IUPAC Name : ditrichloromethyl carbonateCAS NO.:32315-10-9Molecular Weight : Molecular formula: C3Cl6O3Smiles: ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)ClDescription: Triphosgene is used as a carbonylating agent for aza-peptide synthesis.Olodaterol It reacts with…

N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-fluoro-2′-deoxyadenosine-3′-(2-cyanoethyl diisopropylphosphoramidite), 98%

Product Name : N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine-3'-(2-cyanoethyl diisopropylphosphoramidite), 98%Synonym: IUPAC Name : N-{9--5-(2-cyanoethoxy)phosphanyl}oxy)methyl]-3-fluorooxolan-2-yl]-9H-purin-6-yl}benzamideCAS NO.Fluorinert FC-40 :136834-22-5Molecular Weight : Molecular formula: C47H51FN7O7PSmiles: COC1=CC=C(C=C1)C(O1(COP(OCCC#N)N(C(C)C)C(C)C)O(1F)N1C=NC2=C(NC(=O)C3=CC=CC=C3)N=CN=C12)(C1=CC=CC=C1)C1=CC=C(OC)C=C1Description: Midostaurin PMID:24578169

Elacridar

Product Name : ElacridarSynonym: IUPAC Name : N-{4-phenyl}-5-methoxy-9-oxo-9,10-dihydroacridine-4-carboxamideCAS NO.:143664-11-3Molecular Weight : Molecular formula: C34H33N3O5Smiles: COC1=C2NC3=C(C=CC=C3C(=O)C2=CC=C1)C(=O)NC1=CC=C(CCN2CCC3=CC(OC)=C(OC)C=C3C2)C=C1Description: Salmeterol Polydatin PMID:24238415 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals…

3-Cyanopyridine, 98%

Product Name : 3-Cyanopyridine, 98%Synonym: IUPAC Name : pyridine-3-carbonitrileCAS NO.Tenofovir Disoproxil :100-54-9Molecular Weight : Molecular formula: C6H4N2Smiles: N#CC1=CC=CN=C1Description: Paricalcitol PMID:23290930 MedChemExpress (MCE) offers a wide range of high-quality research chemicals…

4-Fluoro-N-Fmoc-L-phenylalanine, 95%

Product Name : 4-Fluoro-N-Fmoc-L-phenylalanine, 95%Synonym: IUPAC Name : (2S)-2-({carbonyl}amino)-3-(4-fluorophenyl)propanoic acidCAS NO.:169243-86-1Molecular Weight : Molecular formula: C24H20FNO4Smiles: OC(=O)(CC1=CC=C(F)C=C1)NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C12Description: 4-Fluoro-N-Fmoc-L-phenylalanine derivative was introduced in collaboration with Yu and coworkers in reflection to…

N-(Hydroxymethyl)phthalimide, 97%

Product Name : N-(Hydroxymethyl)phthalimide, 97%Synonym: IUPAC Name : 2-(hydroxymethyl)-2,3-dihydro-1H-isoindole-1,3-dioneCAS NO.:118-29-6Molecular Weight : Molecular formula: C9H7NO3Smiles: OCN1C(=O)C2=CC=CC=C2C1=ODescription: Romidepsin Clascoterone PMID:24059181 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and…

Calix[4]arene, 98%

Product Name : Calixarene, 98%Synonym: IUPAC Name : pentacyclooctacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrolCAS NO.Fmoc-Thr(tBu)-OH :74568-07-3Molecular Weight : Molecular formula: C28H24O4Smiles: OC1=C2CC3=CC=CC(CC4=CC=CC(CC5=CC=CC(CC1=CC=C2)=C5O)=C4O)=C3ODescription: Functionalized calixarenes can bind DNA and induce cell transfection.TCEP hydrochloride Calixarenes lend themselves…

5-Fluoro-2-nitroaniline, 97%

Product Name : 5-Fluoro-2-nitroaniline, 97%Synonym: IUPAC Name : 5-fluoro-2-nitroanilineCAS NO.:2369-11-1Molecular Weight : Molecular formula: C6H5FN2O2Smiles: NC1=CC(F)=CC=C1()=ODescription: 5-Fluoro-2-nitroaniline as a intermediate in organic synthesis.Paliperidone Valecobulin hydrochloride PMID:24455443 MedChemExpress (MCE) offers a…

Oxacillin sodium salt monohydrate, 815^mg/mg

Product Name : Oxacillin sodium salt monohydrate, 815^mg/mgSynonym: IUPAC Name : sodium (2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-1,2-oxazole-4-amido)-7-oxo-4-thia-1-azabicycloheptane-2-carboxylate hydrateCAS NO.:7240-38-2Molecular Weight : Molecular formula: C19H20N3NaO6SSmiles: O..CC1=C(C(=O)N23SC(C)(C)(N3C2=O)C()=O)C(=NO1)C1=CC=CC=C1Description: Used primarily against Gram-positive organisms namely resistant Staphylococcus speciesAfoxolaner…

2,4,6-Tri-tert-butylaniline, 95%

Product Name : 2,4,6-Tri-tert-butylaniline, 95%Synonym: IUPAC Name : 2,4,6-tri-tert-butylanilineCAS NO.:961-38-6Molecular Weight : Molecular formula: C18H31NSmiles: CC(C)(C)C1=CC(=C(N)C(=C1)C(C)(C)C)C(C)(C)CDescription: 2,4,6-Tri-tert-butylnitrobenzene (bulky amine) is used in the synthesis of monomeric iminophosphoraneTrilostane Quercetin PMID:23962101

2-Methylanthraquinone, 97%

Product Name : 2-Methylanthraquinone, 97%Synonym: IUPAC Name : 2-methyl-9,10-dihydroanthracene-9,10-dioneCAS NO.:84-54-8Molecular Weight : Molecular formula: C15H10O2Smiles: CC1=CC=C2C(=O)C3=CC=CC=C3C(=O)C2=C1Description: 2-Methylanthraquinone is used as a pharmaceutical intermediate.Calcitonin (salmon) It is used in smog dyes.Atracurium…

beta-Nicotinamide adenine dinucleotide phosphate reduced tetrasodium salt, 95%

Product Name : beta-Nicotinamide adenine dinucleotide phosphate reduced tetrasodium salt, 95%Synonym: IUPAC Name : tetrasodium methyl ({methyl phosphonato}oxy)phosphonateCAS NO.:2646-71-1Molecular Weight : Molecular formula: C21H26N7Na4O17P3Smiles: .Digitoxigenin .Sonelokimab .PMID:24516446 .NC(=O)C1=CN(C=CC1)1O(COP()(=O)OP()(=O)OC2O((OP()()=O)2O)N2C=NC3=C(N)N=CN=C23)(O)1ODescription: NADPH tetra…

Thapsigargin, 97%

Product Name : Thapsigargin, 97%Synonym: IUPAC Name : (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azulenofuran-7-yl octanoateCAS NO.Regorafenib :67526-95-8Molecular Weight : Molecular formula: C34H50O12Smiles: CCCCCCCC(=O)O1(OC(=O)C(\C)=C/C)C(C)=C23OC(=O)(C)(O)3(O)(C(C)(OC(C)=O)12)OC(=O)CCCDescription: Cibinetide PMID:26760947

Chlorogenic acid

Product Name : Chlorogenic acidSynonym: IUPAC Name : (1S,3R,4R,5R)-3-{oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acidCAS NO.:327-97-9Molecular Weight : Molecular formula: C16H18O9Smiles: O1C(O)(C(OC(=O)\C=C\C2=CC=C(O)C(O)=C2)1O)C(O)=ODescription: Chlorogenic acid is used as a food additive in coffee products, chewing gum…

ESNP locationPCR amplification primer sequence (5' ?3') aGccatcGat aGtcGaaacG taGGcacGaat ttGcttGaa tccaaGcGta tGctcaaGaa GcacaataGc GaGatGGtca

ESNP locationPCR amplification primer sequence (5' ?3') aGccatcGat aGtcGaaacG taGGcacGaat ttGcttGaa tccaaGcGta tGctcaaGaa GcacaataGc GaGatGGtca taatcctGGcG atGaGatcc tttGccaaGc tcctccatac GaacctcGca tGGttGaGat aGGGcacttG GttccaGata GctcatcaGG cttttGGaaG GcacaaGcca cccactattt GctcatcaGG cttttGGaaG GcacaaGcca…

Ortunities for escalating inhibitor selectivity.Aoyagi-Scharber et al.Acta Cryst. (2014). F70, 1143?BMNstructural communications4. DiscussionRecent efforts in

Ortunities for escalating inhibitor selectivity.Aoyagi-Scharber et al.Acta Cryst. (2014). F70, 1143?BMNstructural communications4. DiscussionRecent efforts in PARP inhibitor design and style have certainly centered on targeting sequence-variable and/or structure-variable regions outside…